Mechanism of substance P-induced granulocyte infiltration in mouse skin.
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Mechanism of substance P-induced liquid secretion across bronchial epithelium.
The present study was undertaken to identify and determine the mechanism of noncholinergic pathways for the induction of liquid secretion across airway epithelium. Excised porcine bronchi secreted substantial and significant quantities of liquid when exposed to acetylcholine, substance P, or forskolin but not to isoproterenol, norepinephrine, or phenylephrine. Bumetanide, an inhibitor of Na(+)-...
متن کاملGranulocyte-dependent autoantibody-induced skin blistering.
Autoimmune phenomena occur in healthy individuals, but when self-tolerance fails, the autoimmune response may result in specific pathology. According to Witebsky's postulates, one of the criteria in diagnosing a disease as autoimmune is the reproduction of the disease in experimental animals by the passive transfer of autoantibodies. For epidermolysis bullosa acquisita (EBA), a prototypic organ...
متن کاملThe NH2-terminus of substance P modulates NMDA-induced activity in the mouse spinal cord.
Excitatory amino acids (EAAs) and substance P are believed to transmit nociceptive information in the spinal cord. As substance P NH2-terminal fragments can modulate non-NMDA EAA-mediated activity, we examined the effects of substance P fragments to ascertain whether the COOH- or NH2-terminus of substance P modulates the actions of NMDA in the spinal cord. NMDA activity was measured by the inte...
متن کاملAmino terminus of substance P potentiates kainic acid-induced activity in the mouse spinal cord.
Sensitization to the behavioral effects produced by repeated injections of kainic acid (KA) into the mouse spinal cord area has been previously shown to be abolished by pretreatment with capsaicin, a neurotoxin of substance P (SP)-containing primary afferent C-fibers. While SP has a variety of well characterized biological actions that are mediated by interactions of its COOH terminus with neur...
متن کاملEffects of a Skin Neuropeptide (Substance P) on Cutaneous Microflora
BACKGROUND Skin is the largest human neuroendocrine organ and hosts the second most numerous microbial population but the interaction of skin neuropeptides with the microflora has never been investigated. We studied the effect of Substance P (SP), a peptide released by nerve endings in the skin on bacterial virulence. METHODOLOGY/PRINCIPAL FINDINGS Bacillus cereus, a member of the skin transi...
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ژورنال
عنوان ژورنال: Ensho
سال: 1992
ISSN: 0389-4290,1884-4006
DOI: 10.2492/jsir1981.12.519